Xie Y, Zhang J, Yin S, and Loo JA. “Top-Down ESI-ECD-FT-ICR Mass Spectrometry Localizes Noncovalent Protein-Ligand Binding Sites.” J Am Chem Soc 2006; 128: 14432-14433.
relevant research
Top-Down ESI-ECD-FT-ICR Mass Spectrometry Localizes Noncovalent Protein-Ligand Binding Sites.
Sizing Large Proteins and Protein Complexes by Electrospray Ionization Mass Spectrometry and Ion Mobility.
Kaddis CS, Lomeli SH, Yin S, Berhane B, Apostol MI, Kickhoefer VA, Rome LH, and Loo JA. “Sizing Large Proteins and Protein Complexes by Electrospray Ionization Mass Spectrometry and Ion Mobility.” J Am Soc Mass Spectrom 2007; 18: 1206-1216.
Lysine-specific molecular tweezers are broad-spectrum inhibitors of assembly and toxicity of amyloid proteins.
Yin S and Loo JA. “Top-Down Mass Spectrometry of Supercharged Native Protein-Ligand Complexes.” Int J Mass Spectrom 2011; 300: 118-122.
Top-Down Mass Spectrometry of Supercharged Native Protein-Ligand Complexes.
Sinha S, Attar A, Maiti P, Du Z, Tan M, Pang ES, Lopes DHJ, Tseng C-H, Jones MR, Talbiersky P, Tennstädt A, Lichti-Kaiser K, Liu T, Yang F, Bakshi R, Kuo P-Y, Lomakin A, Gale GD, Benedek GB, Staudinger JL, Ehrmann M, Loo JA, Xie C-W, Klärner F-G, Schrader T, Wang C, Frautschy SA, and Bitan G. “Lysine-specific molecular tweezers are broad-spectrum inhibitors of assembly and toxicity of amyloid proteins.” J Am Chem Soc 2011; 133: 16958–16969.
Staphylococcus aureus uses a novel multidomain receptor to break apart human hemoglobin and steal its heme.
Spirig T, Malmirchegini GR, Zhang J, Robson S, Sjodt M, Liu M, Kumar KK, Dickson CF, Gell DA, Lei B, Loo JA, and Clubb RT. “Staphylococcus aureus uses a novel multidomain receptor to break apart human hemoglobin and steal its heme.” J Biol Chem 2013; 288: 1065-1078.
Molecular Basis for Preventing α-Synuclein Aggregation by a Molecular Tweezer.
Acharya S, Safaie BM, Wongkongkathep P, Ivanova MI, Attar A, Klärner F-G, Schrader T, Loo JA, Bitan G, and Lapidus LJ. “Molecular Basis for Preventing α-Synuclein Aggregation by a Molecular Tweezer.” J Biol Chem 2014; 289: 10727-10737.
Native Top-Down Electrospray Ionization-Mass Spectrometry of 158 kDa Protein Complex by High-Resolution Fourier Transform Ion Cyclotron Resonance Mass Spectrometry.
Li H, Wolff JJ, Van Orden SL, and Loo JA. “Native Top-Down Electrospray Ionization-Mass Spectrometry of 158 kDa Protein Complex by High-Resolution Fourier Transform Ion Cyclotron Resonance Mass Spectrometry.” Anal Chem 2014; 86: 317−320.
Revealing Ligand Binding Sites and Quantifying Subunit Variants of Non-Covalent Protein Complexes in a Single Native Top-Down FTICR MS Experiment.
Li H, Wongkongkathep P, Van Orden SL, Ogorzalek Loo RR, and Loo JA. “Revealing Ligand Binding Sites and Quantifying Subunit Variants of Non-Covalent Protein Complexes in a Single Native Top-Down FTICR MS Experiment.” J Am Soc Mass Spectrom 2014; 25: 2060-2068.