Human saliva proteome analysis and disease biomarker discovery.

Electrospray-Assisted Laser Desorption Ionization (ELDI) and Tandem Mass Spectrometry of Peptides and Proteins.

Peng IX, Shiea J, Ogorzalek Loo RR, and Loo JA. “Electrospray-Assisted Laser Desorption Ionization (ELDI) and Tandem Mass Spectrometry of Peptides and Proteins.” Rapid Commun Mass Spectrom 2007; 21: 2541–2546.

Pro-oxidative DEP chemicals induce heat shock proteins and an unfolding protein response in a bronchial epithelial cell line as determined by DIGE analysis.

Hu S, Loo JA, and Wong DT. “Human saliva proteome analysis and disease biomarker discovery.” Expert Rev Proteomics 2007; 4: 531-538.

Jung EJ, Avliyakulov NK, Boontheung P, Loo JA, and Nel AE. “Pro-oxidative DEP chemicals induce heat shock proteins and an unfolding protein response in a bronchial epithelial cell line as determined by DIGE analysis.” Proteomics 2007; 7: 3906-3918.

Protein-sequence polymorphisms and post-translational modifications in proteins from human saliva using top down Fourier-transform ion cyclotron resonance mass spectrometry.

Whitelegge JP, Zabrouskov V, Halgand F, Souda P, Bassilian S, Yan W, Wolinsky L, Loo JA, Wong DTW, and Faull KF. “Protein-sequence polymorphisms and post-translational modifications in proteins from human saliva using top down Fourier-transform ion cyclotron resonance mass spectrometry.” Int J Mass Spectrom 2007; 268: 190-197.

Comparison of various nano-differential mobility analysers (nDMAs) applying globular proteins.

Laschober C, Kaddis CS, Reischl GP, Loo JA, Allmaier G, and Szymanski WW. “Comparison of various nano-differential mobility analysers (nDMAs) applying globular proteins.” J Exp Nanosci 2007; 2: 291-301.

Slippery when Translated: Extensive Programmed Ribosomal Frameshifting Revealed by Proteomics.

Ogorzalek Loo R, Yang Y, Xie Y, Dunsmore J, Mouttaki H, McInerney M, Gunsalus R, and Loo J. “Slippery when Translated: Extensive Programmed Ribosomal Frameshifting Revealed by Proteomics.” J Biomol Tech. 2007; 18: 60. PMCID: PMC2291868

Fractionation or Affinity Purification? Using Microcolumns (TiO2, SCX, HILIC) to Isolate Phosphopeptides.

Ytterberg AJ, Ogorzalek Loo RR, Boontheung P, and Loo JA. “Fractionation or Affinity Purification? Using Microcolumns (TiO2, SCX, HILIC) to Isolate Phosphopeptides.” J Biomol Tech 2007; 18: 29–30.

Identification and Solution Structure of a Highly Conserved C-terminal Domain within ORF1p Required for Retrotransposition of Long Interspersed Nuclear Element-1.

Januszyk K, Li P W-L, Villareal V, Branciforte D, Wu H, Xie Y, Feigon J, Loo JA, Martin SL, and Clubb RT. “Identification and Solution Structure of a Highly Conserved C-terminal Domain within ORF1p Required for Retrotransposition of Long Interspersed Nuclear Element-1.” J Biol Chem 2007; 282: 24893–24904.

Salivary Proteomic and Genomic Biomarkers for Primary Sjögren’s Syndrome.

Hu S, Wang J, Meijer J, Ieong S, Xie Y, Yu T, Zhou H, Henry S, Vissink A, Pijpe J, Kallenberg C, Elashoff D, Loo JA, Wong DT. “Salivary Proteomic and Genomic Biomarkers for Primary Sjögren’s Syndrome.” Arthrit Rheum 2007; 56: 3588-3600.

Discovery of oral fluid biomarkers for human oral cancer by mass spectrometry.

Hu S, Yu T, Xie Y, Yang Y, Li Y, Zhou X, Tsung S, Loo RR, Loo JA, and Wong DT. “Discovery of oral fluid biomarkers for human oral cancer by mass spectrometry.” Cancer Genomics Proteomics 2007; 4: 55-64.

Similar enzymes, different structures: Phthalate dioxygenase is an a3a3 stacked hexamer, not an a3b3 trimer like “normal” Rieske oxygenases.

Tarasev M, Kaddis CS, Yin S, Loo JA, Burgner J, and Ballou DP. “Similar enzymes, different structures: Phthalate dioxygenase is an a3a3 stacked hexamer, not an a3b3 trimer like “normal” Rieske oxygenases.” Arch Biochem Biophys 2007; 466: 31-39.

Sizing Large Proteins and Protein Complexes by Electrospray Ionization Mass Spectrometry and Ion Mobility.

Kaddis CS, Lomeli SH, Yin S, Berhane B, Apostol MI, Kickhoefer VA, Rome LH, and Loo JA. “Sizing Large Proteins and Protein Complexes by Electrospray Ionization Mass Spectrometry and Ion Mobility.” J Am Soc Mass Spectrom 2007; 18: 1206-1216.

Human saliva proteome analysis.

Hu S, Loo JA, and Wong DT. “Human saliva proteome analysis.” Ann NY Acad Sci 2007; 1098(Oral-Based Diagnostics): 323-329.

Proinflammatory stimuli induce IKKα-mediated phosphorylation of PIAS1 to restrict inflammation and immunity.

Liu B, Yang Y, Chernishof V, Ogorzalek Loo RR, Jang H, Tahk S, Yang R, Mink S, Shultz D, Bellone CJ, Loo JA, and Shuai K. “Proinflammatory stimuli induce IKKα-mediated phosphorylation of PIAS1 to restrict inflammation and immunity.” Cell 2007; 129: 903-914.

Matrix-Assisted Laser Desorption/Ionization-Mass Spectrometry of Hydrophobic Proteins in Mixtures Using Formic Acid, Perfluorooctanoic Acid, and Sorbitol,

Ogorzalek Loo RR and Loo JA. “Matrix-Assisted Laser Desorption/Ionization-Mass Spectrometry of Hydrophobic Proteins in Mixtures Using Formic Acid, Perfluorooctanoic Acid, and Sorbitol,” Anal Chem 2007; 79: 1115-1125.

Recommended criteria for the mass spectrometric identification of target peptides and proteins (< 8 kDa) in sports drug testing.

Thevis M, Loo JA, Ogorzalek Loo RR, and Schänzer W. “Recommended criteria for the mass spectrometric identification of target peptides and proteins (< 8 kDa) in sports drug testing.” Rapid Commun Mass Spectrom 2007; 21: 297-304.

Mapping the Interaction of Cofilin with Subdomain 2 on Actin.

Benchaar SA, Xie Y, Phillips M, Ogorzalek Loo RR, Galkin VE, Orlova A, Thevis M, Muhlrad A, Almo SC, Loo JA, Egelman EH, and Reisler E. “Mapping the Interaction of Cofilin with Subdomain 2 on Actin.” Biochemistry 2007; 46: 225-233.

Heme is involved in microRNA processing.

Faller M, Matsunaga M, Yin S, Loo JA, and Guo F. “Heme is involved in microRNA processing.” Nature Struct Mol Biol 2007; 14: 23-29. (cover article) (Addendum: Nature Struct Mol Biol 2008; 15: 1125)