Enhancing Sensitivity of Liquid Chromatography/Mass Spectrometry of Peptides and Proteins Using Supercharging Agents.

Nshanian M, Lakshmanan R, Chen H, Ogorzalek Loo RR, and Loo JA. “Enhancing Sensitivity of Liquid Chromatography/Mass Spectrometry of Peptides and Proteins Using Supercharging Agents.” Int. J. Mass Spectrom. 2018; 427: 157-164.

Submicrometer Emitter ESI Tips for Native Mass Spectrometry of Membrane Proteins in Ionic and Non-ionic Detergents.

Susa AC, Lippens JL, Xia Z, Loo JA, Campuzano IDG, and Williams ER. “Submicrometer Emitter ESI Tips for Native Mass Spectrometry of Membrane Proteins in Ionic and Non-ionic Detergents.” J. Am. Soc. Mass Spectrom. 2018; 29: 203-206.

Fourier Transform-Ion Cyclotron Resonance Mass Spectrometry as a Platform for Characterizing Multimeric Membrane Protein Complexes.

Lippens JL, Nshanian M, Spahr C, Egea PF, Loo JA, and Campuzano IDG. “Fourier Transform-Ion Cyclotron Resonance Mass Spectrometry as a Platform for Characterizing Multimeric Membrane Protein Complexes.” J. Am. Soc. Mass Spectrom. 2018; 29: 183-193.

An Integrated Native Mass Spectrometry and Top-Down Proteomics Method that Connects Sequence to Structure and Function of Macromolecular Complexes.

Li H, Nguyen HH, Ogorzalek Loo RR, Campuzano IDG, and Loo JA. “An Integrated Native Mass Spectrometry and Top-Down Proteomics Method that Connects Sequence to Structure and Function of Macromolecular Complexes.” Nature Chem. 2018; 10: 139-148.

4-(Nitrophenylsulfonyl)piperazines mitigate radiation damage to multiple tissues.

Micewicz ED, Kim K, Iwamoto KS, Ratikan JA, Cheng G, Boxx GM, Damoiseaux RD, Whitelegge JP, Ruchala P, Nguyen C, Purbey P, Loo J, Deng G, Jung ME, Sayre JW, Norris AJ, Schaue D, and McBride WH. “4-(Nitrophenylsulfonyl)piperazines mitigate radiation damage to multiple tissues.” PLoS One 2017; 12(7): e0181577.

Supramolecular Modulation of Structural Polymorphism in Pathogenic α-Synuclein Fibrils Using Copper(II) Coordination.

Choi TS, Lee J, Han JY, Jung BC, Wongkongkathep P, Loo JA, Lee MJ, and Kim HI. “Supramolecular Modulation of Structural Polymorphism in Pathogenic α-Synuclein Fibrils Using Copper(II) Coordination.” Angew. Chem. Int. Ed. 2018; 57, 3099-3103.

Fixed-Charge Trimethyl Pyrilium Modification for Enabling Enhanced Top-Down Mass Spectrometry Sequencing of Intact Protein Complexes.

Polasky DA, Lermyte F, Nshanian M, Sobott F, Andrews PC, Loo JA, and Ruotolo BT. “Fixed-Charge Trimethyl Pyrilium Modification for Enabling Enhanced Top-Down Mass Spectrometry Sequencing of Intact Protein Complexes.” Anal. Chem. 2018; 90: 2756−2764.

Radical solutions: Principles and application of electron-based dissociation in mass spectrometry-based analysis of protein structure.

Lermyte F, Valkenborg D, Loo JA, and Sobott F. “Radical solutions: Principles and application of electron-based dissociation in mass spectrometry-based analysis of protein structure.” Mass Spectrom. Rev. 2018; 37: 750–771.

Native-MS Analysis of Monoclonal Antibody Conjugates by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry.

Campuzano IDG, Netirojjanakul C, Nshanian M, Lippens JL, Kilgour D, Van Orden S and Loo JA. “Native-MS Analysis of Monoclonal Antibody Conjugates by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry.” Anal. Chem. 2018; 90: 745−751.

How many human proteoforms are there?

Aebersold R, Agar JN, Amster IJ, Baker MS, Bertozzi CR, Boja ES, Costello CC, Cravatt BF, Fenselau C, Garcia BA, Ge Y, Gunawardena J, Hendrickson RC, Hergenrother PJ, Huber CG, Ivanov AR, Jensen ON, Jewett MC, Kelleher NL, Kiessling LL, Krogan NJ, Larsen MR, Loo JA, Ogorzalek Loo RR, Lundberg E, MacCoss MJ, Mallick P, Mootha VK, Mrksich M, Muir TW, Patrie SM, Pesavento JJ, Pitteri SJ, Rodriguez H, Saghatelian A, Sandoval W, Schluter H, Sechi S, Slavoff SA, Smith LM, Snyder MP, Thomas PM, Uhlen M, Van Eyk JE, Vidal M, Walt DR, White FM, Williams ER, Wohlschlager T, Wysocki VH, Yates NA, Young NL, and Zhang B. “How many human proteoforms are there?” Nature Chem. Biol. 2018; 14: 206-214

ProForma: A Standard Proteoform Notation.

Le Duc RD, Schwammle V, Shortreed MR, Cesnik AJ, Solntsev SK, Shaw JB, Martin MJ, Vizcaino JA, Alpi E, Danis P, Kelleher NL, Smith LM, Ge Y, Agar JN, Chamot-Rooke J, Loo JA, Pasa-Tolic L, and Tsybin YO. “ProForma: A Standard Proteoform Notation.” J. Proteome Res. 2018; 17: 1321-1325.

In vitro reconstitution of sortase-catalyzed pilus polymerization reveals structural elements involved in pilin cross-linking.

Chang C, Amer BR, Osipiuk J, McConnell SA, Huang I-H, Hsieh V, Fu J, Nguyen HH, Muroski J, Flores E, Ogorzalek Loo RR, Loo JA, Putkey JA, Joachimiak A, Das A, Clubb RT, and Ton-That H. “In vitro reconstitution of sortase-catalyzed pilus polymerization reveals structural elements involved in pilin cross-linking.” Proc. Natl. Acad. Sci. USA 2018; 115: E5477-E5486.

Protein Labeling via a Specific Lysine-Isopeptide Bond Using the Pilin Polymerizing Sortase from Corynebacterium diphtheria.

McConnell SA, Amer BR, Muroski J, Fu J, Chang C, Ogorzalek Loo RR, Loo JA, Osipiuk J, Ton-That H, and Clubb RT. “Protein Labeling via a Specific Lysine-Isopeptide Bond Using the Pilin Polymerizing Sortase from Corynebacterium diphtheria.” J. Am. Chem. Soc. 2018; 140: 8420-8423.

Wongkongkathep P, Han JY, Choi TS, Yin S, Kim HI, and Loo JA. “Native Top-Down Mass Spectrometry and Ion Mobility MS for Characterizing the Cobalt and Manganese Metal Binding of α-Synuclein Protein.” J. Am. Soc. Mass Spectrom. 2018; 29: 1870-1880.

Native Top-Down Mass Spectrometry and Ion Mobility MS for Characterizing the Cobalt and Manganese Metal Binding of α-Synuclein Protein.

Cleary SP, Li H, Bagal D, Loo JA, Campuzano IDG, and Prell JS. “Extracting Charge and Mass Information from Highly Congested Mass Spectra Using Fourier-Domain Harmonics.” J. Am. Soc. Mass Spectrom. 2018; 29: 2067-2080.

Extracting Charge and Mass Information from Highly Congested Mass Spectra Using Fourier-Domain Harmonics.

Lippens JL, Egea PF, Spahr C, Vaish A, Keener JE, Marty MT, Loo JA, and Campuzano IDG1. “A Rapid LC-MS Method for Accurate Molecular Weight Determination of Membrane and Hydrophobic Proteins.” Anal. Chem. 2018; 90: 13616-13623.

A Rapid LC-MS Method for Accurate Molecular Weight Determination of Membrane and Hydrophobic Proteins.

Proteomics identification of radiation-induced changes of membrane proteins in the rat model of arteriovenous malformation in pursuit of targets for brain AVM molecular therapy.

Simonian M, Shirasaki D, Lee VS, Bervini D, Grace M, Ogorzalek Loo RR, Loo JA, Molloy MP, and Stoodley MA. “Proteomics identification of radiation-induced changes of membrane proteins in the rat model of arteriovenous malformation in pursuit of targets for brain AVM molecular therapy.” Clin Proteomics 2018; 15: 43 (8 pp).